Supramolecular self-assembly is largely responsible for functional complexity in living systems. We have investigated peptide self-assembly to discern mechanisms of cell/bacteria killing and to create materials with attributes prevalent in biological systems. We are interested in investigating new peptides and peptide self-assembled materials targeting specific bacteria to modify interfaces, and thus prevent infections.
Unraveling dominant surface physicochemistry to build antimicrobial peptide coatings with supramolecular amphiphiles Nanoscale (2020). Z Ye, A. Kobe, T. Sang, C. Aparicio.
Dual self-assembled nanostructure from intrinsically disordered protein polymers with LCST behavior and antimicrobial peptides Biomacromolecules (2020). S. Acosta, Z. Ye, Aparicio C, M. Alonso, J.C. Rodriguez-Cabello