Supramolecular self-assembly is largely responsible for functional complexity in living systems. We have investigated peptide self-assembly to discern mechanisms of cell/bacteria killing and to create materials with attributes prevalent in biological systems. We are interested in investigating new peptides and peptide self-assembled materials targeting specific bacteria to modify interfaces, and thus prevent infections.

Modulation of supramolecular self-assembly of an antimicrobial designer peptide by single amino acid substitution: Implications on peptide activity Nanoscale Advances (2019). Ye Z. and Aparicio C. 

Self-assembly dynamics and Antimicrobial Activity of all L- and D-enantiomers of a Designer Peptide. Nanoscale (2019) 11: 266-275. Z. Ye, X. Zhu, S. Acosta, D. Kumar, T. Sang, C. Aparicio.

Intrafibrillar Mineralization of Self-Assembled Elastin-Like Recombinamer Fibrils. ACS Applied Materials and Interfaces (2017) 9(7):5838–46. Y. Li, J.C. Rodriguez-Cabello, C. Aparicio.