Biomaterials’ clinical outcome is determined by surface interactions with bio-entities (proteins, bacteria, cells, ...). Functionalization of biomaterial surfaces and natural tissues with bio-inspired bioactive molecular systems is a central topic in the 2BI lab. We have designed technologies using peptides, recombinant biopolymers, and proteins to tailor physical and (bio)chemical properties at the material/tissue interface. We are also combining stem cells and surface functionalization technologies to improve performance of devices and scaffolds. Translational potential of our technologies is a key design parameter and goal.

Tapping Basement Membrane Motifs: Oral Junctional Epithelium for Surface-mediated Soft Tissue Attachment to Prevent Failure of Percutaneous Devices Acta Biomaterialia (2022) d.o.i.: j.actbio.2021.12.030. N.G. Fischer, A.C. Kobe, J. Dai, J. He, H. Wang, J.A. Pizarek, D.A. De Jong, Z. Ye, S. Huang, C. Aparicio.

 

Antimicrobial and Enzyme-responsive Multi-peptide Surfaces for Bone-anchored Devices Materials Science and Engineering C (2021) 125:112108. N.G. Fischer, X. Chen, K. Astleford-Hopper, J. He, A.F. Mullikin, K.C. Mansky, C. Aparicio.

 

Harnessing biomolecules for bioinspired dental biomaterials Journal of Materials Chemistry B (2020) 8(38):8713-8747. N.G. Fischer, E.A. Munchow, C. Tamerler, M.C. Bottino, C. Aparicio.

Antibiofilm coating based on protein-engineered polymers and antimicrobial peptides for preventing implant-associated infections Biomaterials Science (2020) 8(10):2866-2877. S. Acosta, A. Ibanez-Fonseca, C. Aparicio,  J.C. Rodriguez-Cabello.

Dual oral tissue adhesive nanofiber membranes for pH-responsive delivery of antimicrobial peptides. Biomacromolecules  (2020) 21 (12): 4945-4961.  S.K. Boda, N.G. Fischer, Z. Ye, C. Aparicio.

 

Dentin priming with amphipathic antimicrobial peptides. Journal of Dental Research (2019) D.G. Moussa, J.A. Kiriharra, Z. Ye, N.G. Fischer, J. Khot, W.A. Witthuhn, C. Aparicio.

Hydrophobic and Antimicrobial Dentin: A Peptide-based 2-tier Protective System for Dental Resin Composite Restorations. Acta Biomaterialia (2019) 88:251-265. D.G. Moussa, A. Fok, C. Aparicio. 

 

Osseointegrated Dental Implant
Mitotic Stem Cells
Biofilm on Hydroxyapatite
Hemidesmosomes in Keratinocytes
Bioactive, Nanoporous Titanium
Multipeptide Coated Surfaces