Biomaterials’ clinical outcome is determined by surface interactions with bio-entities (proteins, bacteria, cells, ...). Functionalization of biomaterial surfaces and natural tissues with bio-inspired bioactive molecular systems is a central topic in the 2BI lab. We have designed technologies using peptides, recombinant biopolymers, and proteins to tailor physical and (bio)chemical properties at the material/tissue interface. We are also combining stem cells and surface functionalization technologies to improve performance of devices and scaffolds. Translational potential of our technologies is a key design parameter and goal.


Physical-chemical interactions between dental materials and Streptococcus gordonii. Colloids and Surfaces B: Biointerfaces (2020) 109, 110938.  T. Sang, Z. Ye, N.G. Fischer, C. Echeverria, J Wu, C. Aparicio.


Dentin priming with amphipathic antimicrobial peptides. Journal of Dental Research (2019) D.G. Moussa, J.A. Kiriharra, Z. Ye, N.G. Fischer, J. Khot, W.A. Witthuhn, C. Aparicio.


Hydrophobic and Antimicrobial Dentin: A Peptide-based 2-tier Protective System for Dental Resin Composite Restorations. Acta Biomaterialia (2019) 88:251-265. D.G. Moussa, A. Fok, C. Aparicio. 


Peptide Coatings to Improve Peri-implant Mucosal Seal. Biomaterials Science (2018) 6, 1936 – 1945. V.P. Koidou, P.P. Argyris, E.P. Skoe, J. Mota Siqueira, X. Chen, L. Zhang, J.E. Hinrichs, M. Costalonga, C. Aparicio.


Osseointegrated Dental Implant
Mitotic Stem Cells
Biofilm on Hydroxyapatite
Hemidesmosomes in Keratinocytes
Bioactive, Nanoporous Titanium
Multipeptide Coated Surfaces