Biomaterials’ clinical outcome is determined by surface interactions with bio-entities (proteins, bacteria, cells, ...). Functionalization of biomaterial surfaces and natural tissues with bio-inspired bioactive molecular systems is a central topic in the 2BI lab. We have designed technologies using peptides, recombinant biopolymers, and proteins to tailor physical and (bio)chemical properties at the material/tissue interface. We are also combining stem cells and surface functionalization technologies to improve performance of devices and scaffolds. Translational potential of our technologies is a key design parameter and goal.


Dentin priming with amphipathic antimicrobial peptides. Journal of Dental Research (2019) D.G. Moussa, J.A. Kiriharra, Z. Ye, N.G. Fischer, J. Khot, W.A. Witthuhn, C. Aparicio.


Hydrophobic and Antimicrobial Dentin: A Peptide-based 2-tier Protective System for Dental Resin Composite Restorations. Acta Biomaterialia (2019) 88:251-265. D.G. Moussa, A. Fok, C. Aparicio. Dentin priming with amphipathic antimicrobial peptides


Peptide Coatings to Improve Peri-implant Mucosal Seal. Biomaterials Science (2018) 6, 1936 – 1945. V.P. Koidou, P.P. Argyris, E.P. Skoe, J. Mota Siqueira, X. Chen, L. Zhang, J.E. Hinrichs, M. Costalonga, C. Aparicio.


In vivo osseointegration of dental implants with an antimicrobial peptide coating. X. Chen, X.C. Zhou, S. Liu, L.F. Wu, C. Aparicio, J.Y. Wu. Journal of Materials Science: Materials in Medicine (2017) 28:76.