Biomaterials’ clinical outcome is determined by surface interactions with bio-entities (proteins, bacteria, cells, ...). Functionalization of biomaterial surfaces and natural tissues with bio-inspired bioactive molecular systems is a central topic in the 2BI lab. We have designed technologies using peptides, recombinant biopolymers, and proteins to tailor physical and (bio)chemical properties at the material/tissue interface. We are also combining stem cells and surface functionalization technologies to improve performance of devices and scaffolds. Translational potential of our technologies is a key design parameter and goal.
Antibiofilm coating based on protein-engineered polymers and antimicrobial peptides for preventing implant-associated infections Biomaterials Science (2020) 8(10):2866-2877. S. Acosta, A. Ibanez-Fonseca, C. Aparicio, J.C. Rodriguez-Cabello.
Dual oral tissue adhesive nanofiber membranes for pH-responsive delivery of antimicrobial peptides. Biomacromolecules (2020) 21 (12): 4945-4961. S.K. Boda, N.G. Fischer, Z. Ye, C. Aparicio.
Dentin priming with amphipathic antimicrobial peptides. Journal of Dental Research (2019) D.G. Moussa, J.A. Kiriharra, Z. Ye, N.G. Fischer, J. Khot, W.A. Witthuhn, C. Aparicio.